Buy FOXO4-DRI (Proxofim) (10mg) peptides, this is an experimental synthetic senolytic peptide that selectively triggers apoptosis in senescent cells by disrupting the interaction between FOXO4 and the p53 protein. By promoting nuclear exclusion of p53, it eliminates damaged aging cells and restores tissue function without harming healthy cells . [1, 2, 3]
Mechanism of Action
Potential Applications
Research on animal models shows promising, yet preliminary, results regarding age-related degradation: [1]
- Vascular Function: Studies show it can suppress aortic aging and alleviate endothelial cell senescence.
- Testicular Aging: It has been observed to target senescent Leydig cells, alleviating age-related testosterone decline and improving spermatogenesis in aged mice.
- Fibrosis: Research indicates it may help in resolving conditions like pulmonary fibrosis and keloid senescent fibroblasts. [1, 2, 3, 4, 5]
For more foundational reading on its structural design, explore the Wikipedia: FOXO4-DRI entry or the Nature Communications: Disordered p53 transactivation domain study on the peptide’s targets. [1]
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- The specific biochemical pathways involved in this peptide’s action?
- Further in vivo and in vitro studies showing its effects on aging or cancer research?
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